The actual problem has nothing to do with disk space. Excel is trying to display a security warning about the file you want to open, but for some reason it is unable to. Security warnings typically come for files you downloaded from the Internet, but not always. To work around this problem, you need to answer the security prompt before Microsoft Excel tries to display it. There are two methods to do this:
Method 1 (by file): Before trying to open the file in Excel, find it in Windows’ File Explorer. Right-click the file and select Properties. At the bottom of the General tab, click the Unblock button. Once you unblock a file, Windows should remember and Excel should not ask you again.
This option is available for some file types, but not others. If you don’t have an Unblock button, use Method 2.
Method 2 (by folder): This option is better if you usually store your downloaded Excel files in one folder. In Excel, click File » Options » Trust Center » Trust Center Settings » Trusted Locations. Click Add new location. Browse to the folder where you store your Excel files, select Subfolders of this location are also trusted, and click OK.
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